Bone Healing Starts Here.

SIGNAFUSE contains a synergistic combination of biomaterials that supports new bone formation.

SIGNAFUSE is designed to provide a rapid bioactive response, optimized resorption profile and unparalleled handling characteristics.

The SIGNAFUSE Difference

  • Bioglass, biphasic β-tricalcium phosphate and hydroxyapatite mineral – this synergistic combination of scientifically validated and clinically supported biomaterials, in the most optimized forms available, provides a bone graft that supports spine fusion and new bone formation.

Moldable to Any Size Defect

  • The resorbable polymer carrier in SIGNAFUSE is designed to provide best-in-class handling, maintaining graft integrity when combined with autologous bone, and resisting displacement during irrigation.


  • SIGNAFUSE features consistent composition without variability inherent in particle size and porosity of tissue based grafts.
  • Biocompatible carrier is designed for rapid elimination through natural metabolic pathways.

Start Fast with Bioglass

  • Patented bioglass size6 (210-420 µm) rapidly creates an osteostimulatory environment and forms an apatite layer as early as seven days, which provides an osteoconductive scaffold to support generation of new osseous tissue.
  • Bioglass has been shown to increase osteoblast differentiation and proliferation, upregulate osteogenic gene expression7-9 and stimulate angiogenesis.7,8

Finish Strong with β-TCP and HA

  • The biphasic mineral, made up of beta-tricalcium phosphate (β-TCP) and hydroxyapatite (HA), promotes new bone formation through a stable, osteoconductive scaffold that is porous and structurally similar to human cancellous bone.
  • The biphasic mineral has a multidirectional interconnected porosity structure that is 20-30% microporous (pore size <10 μm) and 50-55% microporous, which allows for diffusion of biological fluids and offers a large surface area for exchange of calcium and phosphate ions.10,11


Handles Like a Dream

  • Resorbable polymer carrier is designed for best-in-class handling that’s moldable to any size defect.
  • SIGNAFUSE’s carrier demonstrated a greater hydrophilic efficiency than ActifuseTM ABX during benchtop testing. This is critical to allow immediate access to the bone healing effects of the bioactive minerals.12

Let us know how we can help

To request more information on SIGNAFUSE or to contact your local Bioventus Surgical representative to order, please fill out this form.

Instructions For Use
SIGNAFUSE – Instructions for Use

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